Hyaluronic acid is a moisture-binding substance that is naturally found in the human body. With time, our skin loses hyaluronic acid and thus the ability to store moisture, and the rate concentration of hyaluronic acid becomes an indicator of a “young” or “aged” tissue.
Hyaluronic acid has been used in medicine for a long time and over many years has been proven to have an excellent safety property. HA in its natural form, remains in the tissue for only a short amount of time, because of enzymatic degradation and free radical metabolization. To avoid these effects, HA is modified, through crosslinking, to form a water-insoluble polymer hydrogel. This hydrogel is more resistant to degradation but has a similar biocompatibility to non-modified HA.
The extraction of hyaluronic acid (non-animal origin) through bio-fermentation also reduces the likelihood of immune responses to a minimum.
While smaller particles of (HA) (40 – 250 µ) are reabsorbed faster, larger particles (500 µ) are more stable against enzymatic degradation, therefore have a longer duration.