We’re delighted to announce that the latest in vitro study on Genefill DX, the revolutionary hybrid filler developed by BioScience, has just been published.

This research validates what our teams and many practitioners have observed in practice: Genefill DX does more than fill — it hydrates, volumizes, and supports lasting skin rejuvenation at a deeper level.

For the aesthetic professionals committed to evidence‑based results, this study offers fresh data and insight into the biological performance of a filler that embodies BioScience’s dedication to innovation, quality, and skin‑smart design on a cellular level.

What the Study Explores and Why It Matters

This publication represents a comprehensive lab-based assessment of our biostimulatory dermal filler. Rather than focusing only on how you look after treatment, we delved into what’s happening beneath the surface, examining how Genefill DX interacts with key components of skin structure and function.

Using state-of-the-art in vitro testing, the study evaluated:

• The physicochemical and rheological properties of Genefill DX — how it behaves under stress, spreads, and integrates into tissue.
• Its impact on your cells: fibroblast activation, moisture retention, and overall tissue behavior.
• Production of collagen (types I, III, IV, VI) and elastin — proteins essential for firmness, elasticity, and resilience.
• Biological environment modulation — including cytokine balance, which influences inflammation and tissue comfort.
• A head‑to‑head comparison with other widely used agents (HA, HA+CaHA, CaHA, and PLLA fillers) to benchmark performance.
  
  

For anyone evaluating modern filler options or designing aesthetic protocols, this data delivers valuable clarity. It shows what Genefill DX can do cosmetically, as well as focusing on how it interacts with skin biology over time.

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Key Findings That Demonstrate the Genefill DX Advantage

The study uncovered compelling results that help explain why Genefill DX delivers such consistent and desirable outcomes:

• Accelerated tissue response: Under lab conditions, treated tissue showed faster wound healing, about 2-3 times faster than with CaHA fillers, suggesting a superior capacity for recovery and skin resilience.
• Long-lasting collagen and elastin stimulation: The filler significantly increased production of multiple collagen types, along with elastin, contributing to improved skin texture, firmness, and suppleness.
• Sustained hydration: It delivered immediate hydration and maintained it over time, which supports plump, healthy-looking skin.
• Balanced biological activity: Cytokine profiles indicated a favorable, skin‑friendly environment, reducing the likelihood of excessive inflammation while supporting structural renewal.
• Natural movement and integration: Thanks to finely tuned viscoelastic properties, it integrates smoothly into dynamic facial areas, avoiding stiffness or artificial look, and promoting natural-feel results.
  
  

These findings together show that Genefill DX represents a next-generation hybrid filler: one designed for immediate enhancement as well as long‑term skin health and aesthetic harmony.

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Why This Matters

For practitioners:
These findings offer real clinical value. Understanding how Genefill DX performs at the cellular level helps refine treatment choices, personalize techniques, and better align outcomes with patient expectations.

For distributors:
This peer-reviewed study adds scientific strength to the product’s positioning, providing verified data that supports conversations with clients.

For patients:
Genefill DX is all about improving skin quality through volumization, hydration, and natural-looking rejuvenation. With this added transparency, patients can feel more confident in both the product and their results.

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Genefill DX by BioScience: Triple Action, One Filler

With BioScience, you get effective aesthetic treatments that deliver immediate results while respecting the skin’s natural biology, evolving with it over time. Genefill DX reflects this philosophy with its unique triple-action performance:

• Hydration that deeply replenishes moisture to leave skin looking smoother, fresher, and more radiant
• Volumization that gently restores facial contours and enhances definition where it’s needed most
• Rejuvenation that improves skin quality from within by supporting collagen, elastin, and healthier tissue behavior
  
  

This filler is a complete, science-driven approach to facial rejuvenation. One that delivers visible results while preserving natural movement, long-term skin vitality, and authentic expression.

Curious to Explore the Full Study?

The complete article, now published in ISAPS Aesthetic Plastic Surgery, is available to read right here – https://link.springer.com/article/10.1007/s00266-025-05245-5

If you’d like access to more published articles, expert-led webinars, educational courses, and more, you can find it on the BioScience Digital Academy – where education inspires beauty.

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REFERENCE:
Ortiz-Flores RM, Escamilla-Sanchez A, Cidoncha-Morcillo B, Mastronardi L, Fontenete S, Garcia-Delgado R. Enhanced Facial Rejuvenation: Biostimulatory Effects of Hylan Gel Dermal Filler DX on Collagen Synthesis and Tissue Regeneration. Aesthetic Plast Surg. 2025 Oct 13.

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